Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown whether leptin can be effective in the treatment of fully established morbid obesity and its endocrine and metabolic consequences in adults. To test the hypothesis that leptin has a key role in metabolic and...

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Auteurs principaux: Licinio, Julio, Caglayan, Sinan, Ozata, Metin, Yildiz, Bulent O., de Miranda, Patricia B., O'Kirwan, Fiona, Whitby, Robert, Liang, Liyin, Cohen, Pinchas, Bhasin, Shalender, Krauss, Ronald M., Veldhuis, Johannes D., Wagner, Anthony J., DePaoli, Alex M., McCann, Samuel M., Wong, Ma-Li
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2004
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC384781/
https://ncbi.nlm.nih.gov/pubmed/15070752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308767101
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