Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults

Genetic mutations in the leptin pathway can be a cause of human obesity. It is still unknown whether leptin can be effective in the treatment of fully established morbid obesity and its endocrine and metabolic consequences in adults. To test the hypothesis that leptin has a key role in metabolic and...

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Autors principals: Licinio, Julio, Caglayan, Sinan, Ozata, Metin, Yildiz, Bulent O., de Miranda, Patricia B., O'Kirwan, Fiona, Whitby, Robert, Liang, Liyin, Cohen, Pinchas, Bhasin, Shalender, Krauss, Ronald M., Veldhuis, Johannes D., Wagner, Anthony J., DePaoli, Alex M., McCann, Samuel M., Wong, Ma-Li
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC384781/
https://ncbi.nlm.nih.gov/pubmed/15070752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308767101
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