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Tying synaptonemal complex initiation to the formation and programmed repair of DNA double-strand breaks

During meiosis, homologous chromosomes recombine and become closely apposed along their lengths within the synaptonemal complex (SC). In part because Spo11 is required both to make the double-strand breaks (DSBs) that initiate recombination and to promote normal SC formation in many organisms, it is...

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Autori principali: Henderson, Kiersten A., Keeney, Scott
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC384779/
https://ncbi.nlm.nih.gov/pubmed/15070750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400843101
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