Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region. Wwox protein contains two WW domains that are generally known to mediate protein–protein interaction. Here we show that Wwox physically interacts via its first WW domain with the p53 homolog, p73. The tyro...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Aqeilan, Rami I., Pekarsky, Yuri, Herrero, Juan J., Palamarchuk, Alexey, Letofsky, Jean, Druck, Teresa, Trapasso, Francesco, Han, Shuang-Yin, Melino, Gerry, Huebner, Kay, Croce, Carlo M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384759/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15070730/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400805101
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