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Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin

Chloroeremomycin, a vancomycin family glycopeptide antibiotic has three sugars, one d-glucose and two l-4-epi-vancosamines, attached to the crosslinked heptapeptide backbone by three glycosyltransferases, GtfA, -B, and -C. Prior efforts have revealed that GtfB and -C in tandem build an epivancosamin...

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Main Authors: Lu, Wei, Oberthür, Markus, Leimkuhler, Catherine, Tao, Junhua, Kahne, Daniel, Walsh, Christopher T.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC384757/
https://ncbi.nlm.nih.gov/pubmed/15070728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400277101
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