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Identification of DR5 as a critical, NF-κB-regulated mediator of Smac-induced apoptosis

Smac mimetic promotes apoptosis by neutralizing inhibitor of apoptosis (IAP) proteins and is considered as a promising cancer therapeutic. Although an autocrine/paracrine tumor necrosis factor-α (TNFα) loop has been implicated in Smac mimetic-induced cell death, little is yet known about additional...

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Autori principali: Eckhardt, I, Roesler, S, Fulda, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847333/
https://ncbi.nlm.nih.gov/pubmed/24287697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.457
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