Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization

The involvement of ceramide in death receptor-mediated apoptosis has been widely examined with most studies focusing on the role of ceramide generated from sphingomyelin hydrolysis. We now analyze the effect of the ceramide acyl chain length by studying tumor necrosis factor α receptor-1 (TNFR1)-med...

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Main Authors: Ali, M, Fritsch, J, Zigdon, H, Pewzner-Jung, Y, Schütze, S, Futerman, A H
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847327/
https://ncbi.nlm.nih.gov/pubmed/24263103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.451
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