Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization

The involvement of ceramide in death receptor-mediated apoptosis has been widely examined with most studies focusing on the role of ceramide generated from sphingomyelin hydrolysis. We now analyze the effect of the ceramide acyl chain length by studying tumor necrosis factor α receptor-1 (TNFR1)-med...

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Detalhes bibliográficos
Main Authors: Ali, M, Fritsch, J, Zigdon, H, Pewzner-Jung, Y, Schütze, S, Futerman, A H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847327/
https://ncbi.nlm.nih.gov/pubmed/24263103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.451
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