Hepatitis C virus induces a mutator phenotype: Enhanced mutations of immunoglobulin and protooncogenes

Hepatitis C virus (HCV) is a nonretroviral oncogenic RNA virus, which is frequently associated with hepatocellular carcinoma (HCC) and B cell lymphoma. We demonstrated here that acute and chronic HCV infection caused a 5- to 10-fold increase in mutation frequency in Ig heavy chain, BCL-6, p53, and β...

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Detalhes bibliográficos
Main Authors: Machida, Keigo, Cheng, Kevin T.-N., Sung, Vicky M.-H., Shimodaira, Shigetaka, Lindsay, Karen L., Levine, Alexandra M., Lai, Ming-Yang, Lai, Michael M. C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC384729/
https://ncbi.nlm.nih.gov/pubmed/14999097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0303971101
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