Leukemic transformation driven by an ASXL1 mutation after a JAK2V617F-positive primary myelofibrosis: clonal evolution and hierarchy revealed by next-generation sequencing

We have characterized the molecular changes underlying the transformation of a JAK2V617F(+)-myelofibrosis with trisomy 8, into a JAK2V617F-negative leukemia. Leukemic clone did not carry JAK2V617F mutation, but showed ASXL1 mutation (R693X). This mutation was identified in a low percentage at diagno...

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Detalhes bibliográficos
Main Authors: Ferrer-Marín, Francisca, Bellosillo, Beatriz, Martínez-Avilés, Luz, Soler, Gloria, Carbonell, Pablo, Luengo-Gil, Ginés, Caparrós, Eva, Torregrosa, José M, Besses, Carlos, Vicente, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Letter to the Editor
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847205/
https://ncbi.nlm.nih.gov/pubmed/24011025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-6-68
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