Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis

BACKGROUND: In phenylketonuria (PKU), elevated blood phenylalanine (Phe) concentrations are considered to impair transport of large neutral amino acids (LNAAs) from blood to brain. This impairment is believed to underlie cognitive deficits in PKU via different mechanisms, including reduced cerebral...

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Autori principali: de Groot, Martijn J, Hoeksma, Marieke, Reijngoud, Dirk-Jan, de Valk, Harold W, Paans, Anne MJ, Sauer, Pieter JJ, van Spronsen, Francjan J
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847152/
https://ncbi.nlm.nih.gov/pubmed/24007597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-8-133
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