Phenylketonuria: reduced tyrosine brain influx relates to reduced cerebral protein synthesis

BACKGROUND: In phenylketonuria (PKU), elevated blood phenylalanine (Phe) concentrations are considered to impair transport of large neutral amino acids (LNAAs) from blood to brain. This impairment is believed to underlie cognitive deficits in PKU via different mechanisms, including reduced cerebral...

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Detalhes bibliográficos
Main Authors: de Groot, Martijn J, Hoeksma, Marieke, Reijngoud, Dirk-Jan, de Valk, Harold W, Paans, Anne MJ, Sauer, Pieter JJ, van Spronsen, Francjan J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3847152/
https://ncbi.nlm.nih.gov/pubmed/24007597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1172-8-133
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