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Analytic models for mechanotransduction: Gating a mechanosensitive channel

Analytic estimates for the forces and free energy generated by bilayer deformation reveal a compelling and intuitive model for MscL channel gating analogous to the nucleation of a second phase. We argue that the competition between hydrophobic mismatch and tension results in a surprisingly rich stor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wiggins, Paul, Phillips, Rob
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC384697/
https://ncbi.nlm.nih.gov/pubmed/15024097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307804101
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