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Targeting γ-secretase in breast cancer
γ-secretase complexes are multisubunit protease complexes that perform the intramembrane cleavage of more than 60 type-I transmembrane proteins, including Notch receptors. Since dysregulated Notch signaling has been implicated in the tumorigenesis and progression of breast cancer, small molecule γ-s...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove Medical Press
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3846591/ https://ncbi.nlm.nih.gov/pubmed/24367196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/BCTT.S26437 |
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