A Functional Mouse Retroposed Gene Fg01 Reduces Alzheimer’s β-Amyloid Levels and Tau Phosphorylation

Senile plaques consisting of β-amyloid (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). Elucidation of factors that modulate Aβ generation and tau hyperphosphorylation is crucial for AD intervention. Here we identify a...

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Autori principali: Zhang, Yun-wu, Liu, Shijie, Zhang, Xue, Li, Wu-Bo, Chen, Yaomin, Huang, Xiumei, Sun, Liangwu, Luo, Wenjie, Netzer, William J., Threadgill, Richard, Wiegand, Gordon, Wang, Ruishan, Cohen, Stanley N., Greengard, Paul, Liao, Francesca-Fang, Li, Limin, Xu, Huaxi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846276/
https://ncbi.nlm.nih.gov/pubmed/19914182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.08.036
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