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A Functional Mouse Retroposed Gene Fg01 Reduces Alzheimer’s β-Amyloid Levels and Tau Phosphorylation

Senile plaques consisting of β-amyloid (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau are major pathological hallmarks of Alzheimer’s disease (AD). Elucidation of factors that modulate Aβ generation and tau hyperphosphorylation is crucial for AD intervention. Here we identify a...

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Bibliografski detalji
Glavni autori: Zhang, Yun-wu, Liu, Shijie, Zhang, Xue, Li, Wu-Bo, Chen, Yaomin, Huang, Xiumei, Sun, Liangwu, Luo, Wenjie, Netzer, William J., Threadgill, Richard, Wiegand, Gordon, Wang, Ruishan, Cohen, Stanley N., Greengard, Paul, Liao, Francesca-Fang, Li, Limin, Xu, Huaxi
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3846276/
https://ncbi.nlm.nih.gov/pubmed/19914182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.08.036
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