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Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

Identifying factors responsible for variation in drug response is essential for the effective use of targeted therapeutics. We profiled signaling pathway activity in a collection of breast cancer cell lines before and after stimulation with physiologically relevant ligands, which revealed the variab...

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Hlavní autoři: Niepel, Mario, Hafner, Marc, Pace, Emily A., Chung, Mirra, Chai, Diana H., Zhou, Lili, Schoeberl, Birgit, Sorger, Peter K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845839/
https://ncbi.nlm.nih.gov/pubmed/24065145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004379
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