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Profiles of Basal and Stimulated Receptor Signaling Networks Predict Drug Response in Breast Cancer Lines

Identifying factors responsible for variation in drug response is essential for the effective use of targeted therapeutics. We profiled signaling pathway activity in a collection of breast cancer cell lines before and after stimulation with physiologically relevant ligands, which revealed the variab...

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Bibliografiske detaljer
Main Authors: Niepel, Mario, Hafner, Marc, Pace, Emily A., Chung, Mirra, Chai, Diana H., Zhou, Lili, Schoeberl, Birgit, Sorger, Peter K.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845839/
https://ncbi.nlm.nih.gov/pubmed/24065145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2004379
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