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Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

Drug sensitivity and resistance are conventionally quantified by IC(50) or E(max) values, but these metrics are highly sensitive to the number of divisions taking place over the course of a response assay. The dependency of IC(50) and E(max) on division rate creates artefactual correlations between...

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Detalhes bibliográficos
Publicado no:Nat Methods
Main Authors: Hafner, Marc, Niepel, Mario, Chung, Mirra, Sorger, Peter K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887336/
https://ncbi.nlm.nih.gov/pubmed/27135972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.3853
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