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Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence

During retinal development, photoreceptors and bipolar cells express the transcription factor Otx2. Blimp1 is transiently expressed in Otx2+ cells. Blimp1 deletion results in excess bipolar cell formation at the expense of photoreceptors. In principle, Blimp1 could be expressed only in Otx2+ cells t...

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Détails bibliographiques
Auteurs principaux: Brzezinski, Joseph A., Park, Ko Uoon, Reh, Thomas A.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845674/
https://ncbi.nlm.nih.gov/pubmed/24125957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2013.10.006
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