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Prdm1 overexpression causes a photoreceptor fate-shift in nascent, but not mature, bipolar cells

The transcription factors Prdm1 (Blimp1) and Vsx2 (Chx10) work downstream of Otx2 to regulate photoreceptor and bipolar cell fates in the developing retina. Mice that lack Vsx2 fail to form bipolar cells while Prdm1 mutants form excess bipolars at the direct expense of photoreceptors. Excess bipolar...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Dev Biol
Prif Awduron: Goodson, Noah B., Park, Ko U., Silver, Jason S., Chiodo, Vince A., Hauswirth, William W., Brzezinski, Joseph A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386070/
https://ncbi.nlm.nih.gov/pubmed/32562755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2020.06.003
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