Novel Natural Structure Corrector of ApoE4 for Checking Alzheimer's Disease: Benefits from High Throughput Screening and Molecular Dynamics Simulations

A major genetic suspect for Alzheimer's disease is the pathological conformation assumed by apolipoprotein E4 (ApoE4) through intramolecular interaction. In the present study, a large library of natural compounds was screened against ApoE4 to identify novel therapeutic molecules that can preven...

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Main Authors: Goyal, Manisha, Grover, Sonam, Dhanjal, Jaspreet Kaur, Goyal, Sukriti, Tyagi, Chetna, Chacko, Sajeev, Grover, Abhinav
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2013
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845489/
https://ncbi.nlm.nih.gov/pubmed/24324968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/620793
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