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Development of Dual Inhibitors against Alzheimer's Disease Using Fragment-Based QSAR and Molecular Docking

Alzheimer's (AD) is the leading cause of dementia among elderly people. Considering the complex heterogeneous etiology of AD, there is an urgent need to develop multitargeted drugs for its suppression. β-amyloid cleavage enzyme (BACE-1) and acetylcholinesterase (AChE), being important for AD pr...

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Autors principals: Goyal, Manisha, Dhanjal, Jaspreet Kaur, Goyal, Sukriti, Tyagi, Chetna, Hamid, Rabia, Grover, Abhinav
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075005/
https://ncbi.nlm.nih.gov/pubmed/25019089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/979606
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