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Development of Dual Inhibitors against Alzheimer's Disease Using Fragment-Based QSAR and Molecular Docking

Alzheimer's (AD) is the leading cause of dementia among elderly people. Considering the complex heterogeneous etiology of AD, there is an urgent need to develop multitargeted drugs for its suppression. β-amyloid cleavage enzyme (BACE-1) and acetylcholinesterase (AChE), being important for AD pr...

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Dettagli Bibliografici
Autori principali: Goyal, Manisha, Dhanjal, Jaspreet Kaur, Goyal, Sukriti, Tyagi, Chetna, Hamid, Rabia, Grover, Abhinav
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4075005/
https://ncbi.nlm.nih.gov/pubmed/25019089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/979606
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