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Development of Dual Inhibitors against Alzheimer's Disease Using Fragment-Based QSAR and Molecular Docking
Alzheimer's (AD) is the leading cause of dementia among elderly people. Considering the complex heterogeneous etiology of AD, there is an urgent need to develop multitargeted drugs for its suppression. β-amyloid cleavage enzyme (BACE-1) and acetylcholinesterase (AChE), being important for AD pr...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Hindawi Publishing Corporation
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4075005/ https://ncbi.nlm.nih.gov/pubmed/25019089 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/979606 |
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