Pharmacokinetic–pharmacodynamic studies of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor MK-0916 in healthy subjects

AIMS: To characterize pharmacokinetic parameters of MK-0916 and its safety and tolerability in lean, healthy male subjects following single and multiple oral doses. To assess (by stable-isotope labelling) the in vivo inhibition of cortisone-to-cortisol conversion following oral MK-0916. METHODS: Dat...

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Hlavní autoři: Wright, D Hamish, Stone, Julie A, Crumley, Tami M, Wenning, Larissa, Zheng, Wei, Yan, Kerri, Yang, Amy Yifan, Sun, Li, Cilissen, Caroline, Ramael, Steven, Hermanowski-Vosatka, Anne, Langdon, Ronald B, Gottesdiener, Keith M, Wagner, John A, Lai, Eseng
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
Témata:
Pharmacokinetic Dynamic Relationships
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845315/
https://ncbi.nlm.nih.gov/pubmed/23594227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12131
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