Pharmacokinetic interactions and safety evaluations of coadministered tafenoquine and chloroquine in healthy subjects

AIMS: The long-acting 8-aminoquinoline tafenoquine (TQ) coadministered with chloroquine (CQ) may radically cure Plasmodium vivax malaria. Coadministration therapy was evaluated for a pharmacokinetic interaction and for pharmacodynamic, safety and tolerability characteristics. METHODS: Healthy subjec...

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Main Authors: Miller, Ann K, Harrell, Emma, Ye, Li, Baptiste-Brown, Sharon, Kleim, Jőrg-Peter, Ohrt, Colin, Duparc, Stephan, Möhrle, Jörg J, Webster, Alison, Stinnett, Sandra, Hughes, Arlene, Griffith, Sandy, Beelen, Andrew P
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Science Inc 2013
Ábhair:
Clinical Trials
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845309/
https://ncbi.nlm.nih.gov/pubmed/23701202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12160
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