Hemolytic Potential of Tafenoquine in Female Volunteers Heterozygous for Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency (G6PD Mahidol Variant) versus G6PD-Normal Volunteers

Tafenoquine is an 8-aminoquinoline under investigation for the prevention of relapse in Plasmodium vivax malaria. This open-label, dose-escalation study assessed quantitatively the hemolytic risk with tafenoquine in female healthy volunteers heterozygous for the Mahidol(487A) glucose-6-phosphate deh...

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Detalhes bibliográficos
Publicado no:Am J Trop Med Hyg
Main Authors: Rueangweerayut, Ronnatrai, Bancone, Germana, Harrell, Emma J., Beelen, Andrew P., Kongpatanakul, Supornchai, Möhrle, Jörg J., Rousell, Vicki, Mohamed, Khadeeja, Qureshi, Ammar, Narayan, Sushma, Yubon, Nushara, Miller, Ann, Nosten, François H., Luzzatto, Lucio, Duparc, Stephan, Kleim, Jörg-Peter, Green, Justin A.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Tropical Medicine and Hygiene 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590573/
https://ncbi.nlm.nih.gov/pubmed/28749773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.16-0779
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