Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

Matrix mechanics controls cell fate by modulating the bonds between integrins and extracellular matrix (ECM) proteins. However, it remains unclear how fibronectin (FN), type 1 collagen, and their receptor integrin subtypes distinctly control force transmission to regulate focal adhesion kinase (FAK)...

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Hlavní autoři: Seong, Jihye, Tajik, Arash, Sun, Jie, Guan, Jun-Lin, Humphries, Martin J., Craig, Susan E., Shekaran, Asha, García, Andrés J., Lu, Shaoying, Lin, Michael Z., Wang, Ning, Wang, Yingxiao
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845171/
https://ncbi.nlm.nih.gov/pubmed/24222685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1307405110
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