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Mouse model of intrahepatic cholangiocarcinoma validates FIG–ROS as a potent fusion oncogene and therapeutic target

Cholangiocarcinoma is the second most common primary liver cancer and responds poorly to existing therapies. Intrahepatic cholangiocarcinoma (ICC) likely originates from the biliary tree and develops within the hepatic parenchyma. We have generated a flexible orthotopic allograft mouse model of ICC...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Saborowski, Anna, Saborowski, Michael, Davare, Monika A., Druker, Brian J., Klimstra, David S., Lowe, Scott W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3845141/
https://ncbi.nlm.nih.gov/pubmed/24154728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311707110
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