Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

The IFNL4 gene is a recently discovered type III interferon, which in a significant fraction of the human population harbours a frameshift mutation abolishing the IFNλ4 ORF. The expression of IFNλ4 is correlated with both poor spontaneous clearance of hepatitis C virus (HCV) and poor response to tre...

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Autors principals: Hamming, Ole J, Terczyńska-Dyla, Ewa, Vieyres, Gabrielle, Dijkman, Ronald, Jørgensen, Sanne E, Akhtar, Hashaam, Siupka, Piotr, Pietschmann, Thomas, Thiel, Volker, Hartmann, Rune
Format: Artigo
Idioma:Inglês
Publicat: European Molecular Biology Organization 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3844954/
https://ncbi.nlm.nih.gov/pubmed/24169568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.232
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