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Inhibition of the human proteasome by imidazoline scaffolds
The proteasome has emerged as the primary target for the treatment of multiple myeloma. Unfortunately, nearly all patients develop resistance to competitive-type proteasome inhibitors, such as bortezomib. Herein, we describe the optimization of non-competitive proteasome inhibitors to yield derivati...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3844044/ https://ncbi.nlm.nih.gov/pubmed/23789888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400235r |
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