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Substituted quinolines as noncovalent proteasome inhibitors
Screening of a library of diverse heterocyclic scaffolds identified substituted quinolines as inhibitors of the human proteasome. The heterocyclic library was prepared via a novel titanium-catalyzed multicomponent coupling reaction, which rendered a diverse set of isoxazoles, pyrimidines, pyrroles,...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5724766/ https://ncbi.nlm.nih.gov/pubmed/27112450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.04.005 |
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