Substituted quinolines as noncovalent proteasome inhibitors

Screening of a library of diverse heterocyclic scaffolds identified substituted quinolines as inhibitors of the human proteasome. The heterocyclic library was prepared via a novel titanium-catalyzed multicomponent coupling reaction, which rendered a diverse set of isoxazoles, pyrimidines, pyrroles,...

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Vydáno v:Bioorg Med Chem
Hlavní autoři: McDaniel, Tanner J., Lansdell, Theresa A., Dissanayake, Amila A., Azevedo, Lauren M., Claes, Jacob, Odom, Aaron L, Tepe, Jetze J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724766/
https://ncbi.nlm.nih.gov/pubmed/27112450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.04.005
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