µ1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors

The heterotetrameric AP-1 complex is involved in the formation of clathrin-coated vesicles at the trans-Golgi network (TGN) and interacts with sorting signals in the cytoplasmic tails of cargo molecules. Targeted disruption of the mouse µ1A-adaptin gene causes embryonic lethality at day 13.5. In cel...

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Publicat a:	EMBO J
Autors principals:	Meyer, Christoph, Zizioli, Daniela, Lausmann, Susanne, Eskelinen, Eeva-Liisa, Hamann, Jens, Saftig, Paul, von Figura, Kurt, Schu, Peter
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2000
Matèries:	Articles
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10811610/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.10.2193
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