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Binding to E1 and E3 is mutually exclusive for the human autophagy E2 Atg3

Ubiquitin-like proteins (UBLs) are activated, transferred and conjugated by E1-E2-E3 enzyme cascades. E2 enzymes for canonical UBLs such as ubiquitin, SUMO, and NEDD8 typically use common surfaces to bind to E1 and E3 enzymes. Thus, canonical E2s are required to disengage from E1 prior to E3-mediate...

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Bibliografiske detaljer
Main Authors: Qiu, Yu, Hofmann, Kay, Coats, Julie E, Schulman, Brenda A, Kaiser, Stephen E
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843624/
https://ncbi.nlm.nih.gov/pubmed/24186333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2381
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