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A switch element in the autophagy E2 Atg3 mediates allosteric regulation across the lipidation cascade
Autophagy depends on the E2 enzyme, Atg3, functioning in a conserved E1-E2-E3 trienzyme cascade that catalyzes lipidation of Atg8-family ubiquitin-like proteins (UBLs). Molecular mechanisms underlying Atg8 lipidation remain poorly understood despite association of Atg3, the E1 Atg7, and the composit...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6689050/ https://ncbi.nlm.nih.gov/pubmed/31399562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11435-y |
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