Hdac6 regulates Tip60-p400 function in stem cells

In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes required for proliferation and silences genes that promote differentiation. Here we show that the class II histone deacetylase Hdac6 co-purifies with Tip60-p400 complex from ESCs. Hdac6 is necessary for regulation of...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Chen, Poshen B, Hung, Jui-Hung, Hickman, Taylor L, Coles, Andrew H, Carey, James F, Weng, Zhiping, Chu, Feixia, Fazzio, Thomas G
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2013
Schlagworte:
Developmental Biology and Stem Cells
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843111/
https://ncbi.nlm.nih.gov/pubmed/24302573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01557
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