Oral Administration of Transforming Growth Factor-β1 (TGF-β1) Protects the Immature Gut from Injury via Smad Protein-dependent Suppression of Epithelial Nuclear Factor κB (NF-κB) Signaling and Proinflammatory Cytokine Production

Inflammatory immune responses play an important role in mucosal homeostasis and gut diseases. Nuclear factor κB (NF-κB), central to the proinflammatory cascade, is activated in necrotizing enterocolitis (NEC), a devastating condition of intestinal injury with extensive inflammation in premature infa...

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Detalhes bibliográficos
Main Authors: Shiou, Sheng-Ru, Yu, Yueyue, Guo, Yuee, Westerhoff, Maria, Lu, Lei, Petrof, Elaine O., Sun, Jun, Claud, Erika C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843089/
https://ncbi.nlm.nih.gov/pubmed/24129565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503946
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