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VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets

Platelets were activated under the infection with H. pylori in human and mice. We investigated the role of VacA, an exotoxin released by H. pylori in this context. Acid-activated VacA, but not heated VacA, induced platelet CD62P expression. However, VacA reacted with none of the alleged VacA recepto...

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Detalhes bibliográficos
Main Authors: Satoh, Kaneo, Hirayama, Toshiya, Takano, Katsuhiro, Suzuki-Inoue, Katsue, Sato, Tadashi, Ohta, Masato, Nakagomi, Junko, Ozaki, Yukio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842841/
https://ncbi.nlm.nih.gov/pubmed/24219705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-9560-11-23
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