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VacA, the vacuolating cytotoxin of Helicobacter pylori, binds to multimerin 1 on human platelets

Platelets were activated under the infection with H. pylori in human and mice. We investigated the role of VacA, an exotoxin released by H. pylori in this context. Acid-activated VacA, but not heated VacA, induced platelet CD62P expression. However, VacA reacted with none of the alleged VacA recepto...

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Bibliografiske detaljer
Main Authors: Satoh, Kaneo, Hirayama, Toshiya, Takano, Katsuhiro, Suzuki-Inoue, Katsue, Sato, Tadashi, Ohta, Masato, Nakagomi, Junko, Ozaki, Yukio
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842841/
https://ncbi.nlm.nih.gov/pubmed/24219705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-9560-11-23
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