Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase

BACKGROUND: Influenza A virus (IAV) neuraminidase (NA) cleaves sialic acids (Sias) from glycans. Inhibiting NA with oseltamivir suppresses both viral infection, and viral release from cultured human airway epithelial cells. The role of NA in viral exit is well established: it releases budding virion...

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Detalhes bibliográficos
Main Authors: Cohen, Miriam, Zhang, Xing-Quan, Senaati, Hooman P, Chen, Hui-Wen, Varki, Nissi M, Schooley, Robert T, Gagneux, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842836/
https://ncbi.nlm.nih.gov/pubmed/24261589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-10-321
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