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Na(+)/substrate Coupling in the Multidrug Antiporter NorM Probed with a Spin-labeled Substrate

NorM of the multidrug and toxic compound extrusion (MATE) family of transporters couples the efflux of a broad range of hydrophobic molecules to an inward Na(+) gradient across the cell membrane. Several crystal structures of MATE transporters revealed distinct substrate binding sites leading to dif...

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Detalhes bibliográficos
Main Authors: Steed, P. Ryan, Stein, Richard A., Mishra, Smriti, Goodman, Michael C., Mchaourab, Hassane S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842230/
https://ncbi.nlm.nih.gov/pubmed/23902581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi4008935
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