Interferon Regulatory Factors IRF5 and IRF7 Inhibit Growth and Induce Senescence in Immortal Li-Fraumeni Fibroblasts

Cellular immortalization is one of the prerequisite steps in carcinogenesis. By gene expression profiling, we have found that genes in the interferon (IFN) pathway were dysregulated during the spontaneous cellular immortalization of fibroblasts from Li-Fraumeni syndrome (LFS) patients with germ-line...

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Xehetasun bibliografikoak
Egile Nagusiak: Li, Qunfang, Tang, Lin, Roberts, Paul Christopher, Kraniak, Janice M., Fridman, Aviva Levine, Kulaeva, Olga I., Tehrani, Omid S., Tainsky, Michael A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842195/
https://ncbi.nlm.nih.gov/pubmed/18505922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-07-0114
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