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Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations

Germline p53 mutations are frequently observed in the normal DNA of cancer-prone patients with Li-Fraumeni syndrome (LFS). Fibroblasts from LFS patients develop chromosomal aberrations, loss of cell cycle control, and spontaneous immortalization. We transfected four different mutant p53 genes into h...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Philip K, Kraus, Eliyahu, Wu, Tian A, Strong, Louise C, Tainsky, Michael A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 1996
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2719722/
https://ncbi.nlm.nih.gov/pubmed/8649766
Tagiau: Ychwanegu Tag
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