Arming a Replicating Adenovirus with Osteoprotegerin Reduces the Tumor Burden in a Murine Model of Osteolytic Bone Metastases of Breast Cancer

Most patients with advanced breast cancer develop osteolytic bone metastases, which have numerous complications. Because current therapies are not curative, new treatments are needed. Conditionally replicating adenoviruses (CRAds) are anticancer agents designed to infect and lyse tumor cells. Howeve...

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Main Authors: Cody, James J., Rivera, Angel A., Lyons, Gray R., Yang, Sherry W., Wang, Minghui, Sarver, David B., Wang, Dezhi, Selander, Katri S., Kuo, Hui-Chien, Meleth, Sreelatha, Feng, Xu, Siegal, Gene P., Douglas, Joanne T.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3842170/
https://ncbi.nlm.nih.gov/pubmed/20798695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2010.47
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