POLG determines the risk of sodium valproate induced liver toxicity

Sodium valproate (VPA) is widely used throughout the world to treat epilepsy, migraine, chronic headache, bipolar disorder, and as adjuvant chemotherapy. VPA toxicity is an uncommon but potentially fatal cause of idiosyncratic liver injury. Rare mutations in POLG, which codes for the mitochondrial D...

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Detalhes bibliográficos
Main Authors: Stewart, Joanna D., Horvath, Rita, Baruffini, Enrico, Ferrero, Iliana, Bulst, Stefanie, Watkins, Paul B., Fontana, Robert J., Day, Christopher P., Chinnery, Patrick F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841971/
https://ncbi.nlm.nih.gov/pubmed/21038416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23891
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