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α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genes
Mutation of the adenomatous polyposis coli (APC) tumor suppressor stabilizes β-catenin and aberrantly reactivates Wnt/β-catenin target genes in colon cancer. APC mutants in cancer frequently lack the conserved catenin inhibitory domain (CID), which is essential for β-catenin proteolysis. Here we sho...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3841736/ https://ncbi.nlm.nih.gov/pubmed/24240237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.229062.113 |
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