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Repression of Wnt/β-catenin signaling by SOX9 and Mastermind-like transcriptional coactivator 2
Wnt/β-catenin signaling requires inhibition of a multiprotein destruction complex that targets β-catenin for proteasomal degradation. SOX9 is a potent antagonist of the Wnt pathway and has been proposed to act through direct binding to β-catenin or the β-catenin destruction complex. Here, we demonst...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7888933/ https://ncbi.nlm.nih.gov/pubmed/33597243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0849 |
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