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YAP repression of the WNT3 gene controls hESC differentiation along the cardiac mesoderm lineage
Activin/SMAD signaling in human embryonic stem cells (hESCs) ensures NANOG expression and stem cell pluripotency. In the presence of Wnt ligand, the Activin/SMAD transcription network switches to cooperate with Wnt/β-catenin and induce mesendodermal (ME) differentiation genes. We show here that the...
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| Publicado no: | Genes Dev |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5769769/ https://ncbi.nlm.nih.gov/pubmed/29269485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.307512.117 |
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