Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and Memory

Prolyl endopeptidase (PREP) is a phylogenetically conserved serine protease and, in humans and rodents, is highly expressed in the brain. Several neuropeptides associated with learning and memory and neurodegenerative disorders have been proposed to be the substrates for PREP, suggesting a possible...

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Main Authors: D'Agostino, Giuseppe, Kim, Jung Dae, Liu, Zhong-Wu, Jeong, Jin Kwon, Suyama, Shigetomo, Calignano, Antonio, Gao, Xiao-Bing, Schwartz, Michael, Diano, Sabrina
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2013
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841400/
https://ncbi.nlm.nih.gov/pubmed/22767632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhs199
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