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Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement.

Immunoglobulin V kappa genes are transcriptionally silent in their germline context and become transcriptionally active upon fusion to the J kappa-C kappa region (kappa locus). To elucidate the role of chromosomal structure in this regulatory phenomenon we have investigated the DNase I sensitivity a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mather, E L, Perry, R P
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1983
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384109/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6308642/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.15.4689
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