Effects of Oxidative Alcohol Metabolism on the Mitochondrial Permeability Transition Pore and Necrosis in a Mouse Model of Alcoholic Pancreatitis

BACKGROUND & AIMS: Opening of the mitochondrial permeability transition pore (MPTP) causes loss of the mitochondrial membrane potential (ΔΨm) and, ultimately, adenosine triphosphate depletion and necrosis. Cells deficient in cyclophilin D (CypD), a component of the MPTP, are resistant to MPTP op...

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Autores principales: SHALBUEVA, NATALIA, MARENINOVA, OLGA A., GERLOFF, ANDREAS, YUAN, JINGZHEN, WALDRON, RICHARD T., PANDOL, STEPHEN J., GUKOVSKAYA, ANNA S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841074/
https://ncbi.nlm.nih.gov/pubmed/23103769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2012.10.037
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