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SIRT1 Inhibits p53 but not NF-κB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies

BACKGROUND AND OBJECTIVES: SIRT1, a histone diacetylase, modify transactivation function of various transcription factor including p53 and NF-κB. p53 and NF-κB is involved in in vitro differentiation of mouse embryonic stem cells (mESC) into mouse embryoid body (mEB). These suggest that SIRT1 might...

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Bibliographische Detailangaben
Hauptverfasser: Lhee, Sang Jae, Song, Eun-Kyung, Kim, Yu-Ri, Han, Myung-Kwan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Korean Society for Stem Cell Research 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3840997/
https://ncbi.nlm.nih.gov/pubmed/24298365
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